Triethylamine → 2-(N',N'-diethylcarbamoyl)ethyl isocyanate
Reaktionsgleichung
[CH2:1]([N:3]([CH2:11][CH3:12])[C:4]([CH2:6][CH2:7]C(O)=O)=[O:5])[CH3:2].C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:20])C=CC=CC=1.C([N:32]([CH2:35]C)CC)C>C1C=CC=CC=1>[CH2:11]([N:3]([CH2:1][CH3:2])[C:4]([CH2:6][CH2:7][N:32]=[C:35]=[O:20])=[O:5])[CH3:12]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The reaction of 3-(N,N-diethylcarbamoyl)propionic acid and diphenylphosphoryl azide in a solution of triethylamine and benzene provided a solution comprising 2-(N',N'-diethylcarbamoyl)ethyl isocyanate (I.R.: 2290 cm-1), which was reacted with 5-fluorouracil to provide 1-[N-[2-(N',N'-diethylcarbamoyl)ethyl]carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 4.