HCID 20497519, Verbindung → HCID 20524256, Verbindung

HRID 1702981Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1702981
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[N:4]=[C:3]1[NH:14]N>NCCCCO>[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[N:4]=[C:3]1[NH:14][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]

Komponenten

3

Edukt 1

HCID 20497519HCID 20497519, Verbindung

Produkt 1

HCID 20524256HCID 20524256, VerbindungAusbeute 126,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 258684-Amino-1-butanolLösungsmittel

Versuchsvorschrift

20 g of 3-amino-2-hydrazino-6-methylquinazolin-4(3H)-one were stirred in 100 ml of 4-aminobutanol at 175° C. for 24 hours and the majority of the 4-aminobutanol was then distilled off under vacuum. The residue was diluted with water to crystallize out the product and the mixture was filtered. The product was washed and dried to obtain 16.2 g of 3-amino-2-(4-hydroxybutylamino)-6-methylquinazolin-4(3H)-one.

Aufarbeitung

  1. distillationthe majority of the 4-aminobutanol was then distilled off under vacuum
  2. additionThe residue was diluted with water
  3. customto crystallize out the product
  4. filtrationthe mixture was filtered
  5. washThe product was washed
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e28a6e4f926c42078dcb238f07dd8c7b
Quelldatensatz
uspto-grants-1982_09
Patentnummer
US04350695

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