Borane → 4-(Thiophen-2-yl)butan-1-ol

HRID 1703097Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1703097
B.[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][CH2:8][CH2:9][C:10](O)=[O:11]>O1CCCC1>[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][CH2:8][CH2:9][CH2:10][OH:11]

Komponenten

4

Edukt 2

HCID 6331BoraneHCID 783864-(2-Thienyl)Butyric Acid

Produkt 1

HCID 126238624-(Thiophen-2-yl)butan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To 240 ml. of 1 M borane in tetrahydrofuran chilled in an ice bath, is added dropwise, 20.4 g. of 4-(2-thienyl)butyric acid in 50 ml. of tetrahydrofuran. After the addition, the mixture is allowed to stand at room temperature for 17 hours and is poured onto ice. After standing, the mixture is extracted with ether, the ether extract washed with water, dried over magnesium sulfate and concentrated in vacuo to give a pale yellow oil.

Aufarbeitung

  1. additionis added dropwise
  2. additionAfter the addition
  3. additionis poured onto ice
  4. extractionthe mixture is extracted with ether
  5. extractionthe ether extract
  6. washwashed with water
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated in vacuo
  9. customto give a pale yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-1dafd2cf709549f5ba585d6b6c3b5e39
Quelldatensatz
uspto-grants-1982_09
Patentnummer
US04350822

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