Thionyl Chloride → 4-Isopropyl-3-sulfamoylbenzoylchloride
Reaktionsgleichung
[CH:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8](O)=[O:9])=[CH:6][C:5]=1[S:13](=[O:16])(=[O:15])[NH2:14])([CH3:3])[CH3:2].S(Cl)([Cl:19])=O>>[CH:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([Cl:19])=[O:9])=[CH:6][C:5]=1[S:13](=[O:16])(=[O:15])[NH2:14])([CH3:3])[CH3:2]Komponenten
3
Versuchsvorschrift
5 g of 4-isopropyl-3-sulfamoylbenzoic acid were boiled under reflux in 50 ml of thionylchloride until completely dissolved and the reaction mixture was then concentrated to 25 ml under reduced pressure. After allowing to dwell over night at 0° C., the crystals were filtered off over a sinter glass frit and washed with petroleum ether. Colorless body, melting point: 177° C.
Aufarbeitung
- dissolutionuntil completely dissolved
- concentrationthe reaction mixture was then concentrated to 25 ml under reduced pressure
- waitto dwell over night at 0° C.
- filtrationthe crystals were filtered off over a sinter glass frit