2-Propanone, 1-[4-(2-phenoxyethyl)-1-piperazinyl]-1-phenyl- → HCID 3050036, Verbindung

HRID 1704731Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1704731
[O:1]([CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([CH:16]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:17]([CH3:19])=[O:18])[CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[O:1]([CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][N:13]([CH:16]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:17]([OH:18])[CH3:19])[CH2:14][CH2:15]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 30500342-Propanone, 1-[4-(2-phenoxyethyl)-1-piperazinyl]-1-phenyl-

Produkt 1

HCID 3050036HCID 3050036, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To 1-(N-2-phenoxy-ethyl-piperazino)-1-phenylacetone (1 mole) dissolved in anhydrous methanol (1 liter) is added BH4K (1 mole) portionwise, at 0° C., with stirring. On completion of the addition (1 hour), the reaction mixture is stirred 24 hours at room temperature. The methanol is removed in vacuo over a water-bath, the resulting material is then taken up into methylene chloride which is washed with water to neutral pH. Concentration gives white crystals which melt at 100° C.

Aufarbeitung

  1. additionis added BH4K (1 mole) portionwise
  2. additionOn completion of the addition (1 hour)
  3. stirringthe reaction mixture is stirred 24 hours at room temperature
  4. customThe methanol is removed in vacuo over a water-bath
  5. washis washed with water to neutral pH
  6. concentrationConcentration
  7. customgives white crystals which
  8. custommelt at 100° C.

Quellen und Nachweise

ORD-Eintrag
ord-268962db1cb4492fb5cf2efe65386f95
Quelldatensatz
uspto-grants-1978_11
Patentnummer
US04127661

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