Ammonia → 7-(2-Chloro-6-fluorobenzylamino)[1,2,5]thiadiazolo[3,4-d]pyrimidine

HRID 1704779

Reaktionsgleichung

Reaktionsgleichung von HRID 1704779
[NH2:1][C:2]1[C:3]2[C:4](=[N:8][S:9][N:10]=2)[N:5]=[CH:6][N:7]=1.N.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:14]=1[CH2:15]Cl>>[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:14]=1[CH2:15][NH:1][C:2]1[C:3]2[C:4](=[N:8][S:9][N:10]=2)[N:5]=[CH:6][N:7]=1

Komponenten

4

Edukt 3

HCID 222AmmoniaHCID 95769(1,2,5)Thiadiazolo(3,4-d)pyrimidin-7-amineHCID 1086751-Chloro-2-(chloromethyl)-3-fluorobenzene

Produkt 1

HCID 204820257-(2-Chloro-6-fluorobenzylamino)[1,2,5]thiadiazolo[3,4-d]pyrimidineAusbeute 25 %

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

An autoclave was charged with 1.54 g. (0.01 mole) of 7-amino[1,2,5]thiadiazolo[3,4-d]pyrimidine prepared by the process set forth in Example 1, 5.1 g. (0.3 mole) ammonia and 4.48 g. (0.025 mole) 2-chloro-6-fluorobenzyl chloride. The vessel was sealed and the contents heated at 110° C. for 15 hours. After cooling and evaporation of the excess ammonia, the resulting solid was collected by filtration, washed successively with water and hexane to afford a 25% yield of product.

Aufarbeitung

  1. additionAn autoclave was charged with 1.54 g
  2. customThe vessel was sealed
  3. temperatureAfter cooling
  4. customevaporation of the excess ammonia
  5. filtrationthe resulting solid was collected by filtration
  6. washwashed successively with water and hexane

Quellen und Nachweise

ORD-Eintrag
ord-640dc70040b54c33ad486aca2e13e8f2
Quelldatensatz
uspto-grants-1978_11
Patentnummer
US04127721

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