HCID 20333776, Verbindung → HCID 20333770, Verbindung

HRID 1706614Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1706614
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][CH2:10][CH2:9][N:8]=[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])[C:6]=2[CH:19]=1.Cl[CH2:21][CH2:22][C:23]([N:25]=[C:26]=[S:27])=[O:24]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([C:26]3[S:27][CH2:21][CH2:22][C:23](=[O:24])[N:25]=3)[CH2:10][CH2:9][N:8]=[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])[C:6]=2[CH:19]=1

Komponenten

4

Edukt 2

HCID 20333776HCID 20333776, VerbindungHCID 21890227HCID 21890227, Verbindung

Produkt 1

HCID 20333770HCID 20333770, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

5 Parts of 7-chloro-5-(o-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine and 12 parts of 3-chloropropionylisothiocyanate is dissolved in 100 parts by volume of tetrahydrofuran and the resultant solution refluxed for about 18 hours. The reaction mixture is then cooled to ambient temperature and filtered. The solvent is removed from the filtrate and the residue crystallized from a mixture of methylene chloride and hexane to afford 7-chloro-5-(o-chlorophenyl)-2,3-dihydro-1-(5,6-dihydro-4-oxo-4H-1,3-thiazin-2-yl)-1H-1,4-benzodiazepine. This compound is represented by the following formula ##STR31##

Aufarbeitung

  1. filtrationfiltered
  2. customThe solvent is removed from the filtrate
  3. customthe residue crystallized from a mixture of methylene chloride and hexane

Quellen und Nachweise

ORD-Eintrag
ord-f01d85e8fa8c4f9299a08618a01ee113
Quelldatensatz
uspto-grants-1980_06
Patentnummer
US04208327

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