Potassium Hydroxide → N-(Piperidin-4-yl)pyridin-2-amine

HRID 1706729Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1706729
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][CH:8]1[CH2:13][CH2:12][N:11](C(OCC)=O)[CH2:10][CH2:9]1.[OH-].[K+]>CC(O)C>[NH:11]1[CH2:12][CH2:13][CH:8]([NH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:9][CH2:10]1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 11357119Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate

Produkt 1

HCID 21912674N-(Piperidin-4-yl)pyridin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A mixture of 90 parts of ethyl 4-(2-pyridinylamino)-1-piperidinecarboxylate, 90 parts of potassium hydroxide and 720 parts of 2-propanol is stirred and refluxed for 2 days. The reaction mixture is evaporated. 1000 Parts of water are added to the residue and the product is extracted with dichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from 2,2'-oxybispropane, yielding 13 parts of N-(4-piperidinyl)-2-pyridinamine.

Aufarbeitung

  1. temperaturerefluxed for 2 days
  2. customThe reaction mixture is evaporated
  3. addition1000 Parts of water are added to the residue
  4. extractionthe product is extracted with dichloromethane
  5. customThe extract is dried
  6. filtrationfiltered
  7. customevaporated
  8. customThe residue is crystallized from 2,2'-oxybispropane

Quellen und Nachweise

ORD-Eintrag
ord-679566521c114857b8902b9463d538dd
Quelldatensatz
uspto-grants-1980_06
Patentnummer
US04208418

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