Ethyl orthoformate → 6-Phenyl-1,2,4-triazolo[4,3-a]pyrimidine

Reaktionsgleichung

[NH:1]([C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][N:4]=1)[NH2:2].[CH:15](OCC)(OCC)OCC>>[C:9]1([C:6]2[CH:7]=[N:8][C:3]3[N:4]([CH:15]=[N:2][N:1]=3)[CH:5]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

Edukt 2

HCID 31214Ethyl orthoformate

HCID 141699362-Hydrazino-5-phenylpyrimidine

Produkt 1

HCID 203333416-Phenyl-1,2,4-triazolo[4,3-a]pyrimidine

Versuchsvorschrift

A mixture of 2.5 g. of 2-hydrazino-5-phenylpyrimidine and 25 ml. of triethyl orthoformate is heated for 16 hours under reflux. The material that separates is collected and crystallized from ethanol to give 1.5 g. of the product of the Example, m.p. 231° C.

Aufarbeitung

additionA mixture of 2.5 g
temperatureunder reflux
customThe material that separates is collected
customcrystallized from ethanol
customto give 1.5 g

Quellen und Nachweise

ORD-Eintrag: ord-9a4192171b444a14a381a1fef4bfd061
Quelldatensatz: uspto-grants-1980_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04209621

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