Ethanol → Etilevodopa

HRID 1707794

Reaktionsgleichung

Reaktionsgleichung von HRID 1707794
[CH:1]1[C:6]([CH2:7][C@H:8]([NH2:12])[C:9]([OH:11])=[O:10])=[CH:5][C:4]([OH:13])=[C:3]([OH:14])[CH:2]=1.S(Cl)(Cl)=O.[CH2:19](O)[CH3:20]>>[CH3:19][CH2:20][O:10][C:9]([C@@H:8]([NH2:12])[CH2:7][C:6]1[CH:1]=[CH:2][C:3]([OH:14])=[C:4]([OH:13])[CH:5]=1)=[O:11]

Komponenten

4

Edukt 3

HCID 702EthanolHCID 6047LevodopaHCID 24386Thionyl Chloride

Produkt 1

HCID 170345Etilevodopa

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

Levodopa (50 g.) was added in portions to a cooled (2-8° C.) solution of 30 ml. thionyl chloride in 250 ml. absolute ethanol. The resulting mixture was heated to 40° C. for 16 hours and then the volatiles were removed in vacuo. The residue was dissolved in 50 ml. of water and diluted with a solution of 20 g. of sodium bicarbonate, 26 g. of sodium sulfate and 50 mg. of ascorbic acid in 400 ml. of water. The pH of the resulting solution was carefully adjusted to pH 7 with 10% aqueous sodium hydroxide and it was extracted with deaerated free ethyl acetate containing 0.01% BHT.

Aufarbeitung

  1. temperatureThe resulting mixture was heated to 40° C. for 16 hours
  2. customthe volatiles were removed in vacuo
  3. dissolutionThe residue was dissolved in 50 ml
  4. additionof water and diluted with a solution of 20 g
  5. extractionwas extracted with deaerated free ethyl acetate containing 0.01% BHT

Quellen und Nachweise

ORD-Eintrag
ord-3edbbe75c9014aed894cc135a18f0142
Quelldatensatz
uspto-grants-1994_10
Patentnummer
US05354885

Verknüpfte Notizen

Wird geladen…