Sulfur → 2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine

https://huagongshe.com/de/reaction/1708024

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sulfur	HCID 5362487	—
Edukt	3-(1-Acetyl-l,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine	HCID 19957261	—
Lösungsmittel	Decalin	HCID 7044	—
Produkt	2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine	HCID 19957277	49,1%

Reaktionsbedingungen

Temperatur	190 °C

Reaktionsschritte

A mixture of 3-(1-acetyl-1,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine (315 mg) and sulfur (146 mg) in decaline (3 ml) was stirred at 190° C. for 2 hours. The reaction mixture was cooled and purified by column chromatography on silica gel to give 2-(4-fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine (135 mg) as crystals.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05356897
Quelldatensatz	uspto-grants-1994_10
ORD ID	ord-e456eb84833d49f0858b35c8c7319e96
Quellennotiz	uspto-grants-1994_10