Sulfuric Acid → 1H-Imidazole-4-sulfonic acid, 5-chloro-1-methyl-

Reaktionsgleichung

[Cl:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][CH:3]=1.[S:8](=O)(=[O:11])([OH:10])[OH:9]>>[Cl:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[S:8]([OH:11])(=[O:10])=[O:9]

Komponenten

Edukt 2

HCID 1118Sulfuric Acid

HCID 701055-chloro-1-methyl-1H-imidazole

Produkt 1

HCID 30781001H-Imidazole-4-sulfonic acid, 5-chloro-1-methyl-

Versuchsvorschrift

33 g (0.28 mol) of 5-chloro-1-methylimidazole in 200 ml of fuming sulfuric acid are heated at 160°-180° C. for 4 hours. After cooling, the reaction mixture is cautiously added to ice. The product crystallizes out from the cold aqueous solution (about 1.5 l). After recrystallizing twice from water, the title compound is obtained in the form of coarse yellowish crystals of melting point 309°-310° C.

Aufarbeitung

temperatureAfter cooling
additionthe reaction mixture is cautiously added to ice
customThe product crystallizes out from the cold aqueous solution (about 1.5 l)
customAfter recrystallizing twice from water

Quellen und Nachweise

ORD-Eintrag: ord-7052dc25486040758bd707f63fdf2eac
Quelldatensatz: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05356922

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