Methylamine → HCID 15036878, Verbindung
Reaktionsgleichung
[CH3:1][NH2:2].F[C:4]1[N:9]=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:7]=[CH:6][CH:5]=1>>[CH3:1][NH:2][C:4]1[N:9]=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:7]=[CH:6][CH:5]=1Komponenten
3
Versuchsvorschrift
To 10 ml of condensed methylamine was added 1.86 g (10 mmol) of 6-fluoropyridine-2-sulfonamide. The mixture was allowed to reflux under a dry-ice condenser for 4 hr, then excess amine was allowed to evaporate overnight. The residue was crystallized with water to yield 1.64 g of tan solid, m.p. 124° C. to 126° C. NMR (CDCl3): δ 2.64 (s, 3H), 6.12 (br s, 2H), 6.30 (d, 1H), 6.86 (d, 1H), 7.23 (dd, 1H).
Aufarbeitung
- temperatureto reflux under a dry-ice condenser for 4 hr
- customto evaporate overnight
- customThe residue was crystallized with water
Quellen und Nachweise
- ORD-Eintrag
- ord-41059be2bc364f7cb466ed724b32bc13
- Quelldatensatz
- uspto-grants-1990_08
- Patentnummer
- US04946494
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