Hydrochloric Acid → Mdl-27192

HRID 1708907Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1708907
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])=O)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]2[N:12]([CH2:13][CH3:14])[C:10](=[O:11])[NH:9][N:8]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13864336HCID 13864336, Verbindung

Produkt 1

HCID 35793Mdl-27192

Versuchsvorschrift

1-(4-chlorobenzoyl)-4-ethylsemicarbazide (23.7 g, 9.81×10-2 mole) and 1 molar aqueous NaOH (118 ml, 1.18×10-1 mole) were stirred and warmed to reflux. After refluxing 23 hours, heating was discontinued and the reaction was acidified by the dropwise addition of 1 molar aqueous hydrochloric acid (130 ml, 1.30×10-1 mole). A colorless solid formed as the reaction was acidified and, after cooling in an ice bath, this was collected by filtration. Crystallization from isopropanol gave colorless spars: 18.2 g (83%), mp 188°-189°.

Aufarbeitung

  1. temperaturewarmed to reflux
  2. temperatureAfter refluxing 23 hours
  3. temperatureheating
  4. customA colorless solid formed as the reaction
  5. temperatureafter cooling in an ice bath
  6. filtrationthis was collected by filtration
  7. customCrystallization from isopropanol
  8. customgave colorless spars

Quellen und Nachweise

ORD-Eintrag
ord-05f463c5982041c9b099d692c11048e4
Quelldatensatz
uspto-grants-1990_08
Patentnummer
US04946856

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