StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Hydrochloric Acid → 2-(7-Chloro-2,3-dihydro-2-methyl-4-benzofuranyl)-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carboxylic acid

HRID 1709120
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1709120
ClC1[C:10]2OC(C)C[C:6]=2[C:5]([N:12]2[C:17](=[O:18])[NH:16][C:15](=[O:19])C(C#N)=[N:13]2)=[CH:4][CH:3]=1.O1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1.[ClH:28].[C:29]([O:32]CC)(=[O:31])[CH3:30]>>[Cl:28][C:27]1[C:26]2[O:25][CH:24]([CH3:23])[CH2:10][C:6]=2[C:5]([N:12]2[C:17](=[O:18])[NH:16][C:15](=[O:19])[C:30]([C:29]([OH:32])=[O:31])=[N:13]2)=[CH:4][CH:3]=1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 4

HCID 313Hydrochloric Acid2×HCID 8857Ethyl AcetateHCID 312751,4-DioxaneHCID 542357422-(7-Chloro-2,3-dihydro-2-methyl-4-benzofuranyl)-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile

Produkt 1

HCID 541828772-(7-Chloro-2,3-dihydro-2-methyl-4-benzofuranyl)-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carboxylic acid

Versuchsvorschrift

A mixture of 9.0 g of 32C, 150 mL of p-dioxane and 100 mL of 6N hydrochloric acid was stirred at reflux temperature overnight. Then 20 mL of 12N hydrochloric acid was added and the mixture was stirred at reflux temperature for 2 hours, and stripped of solvent. The residue was dissolved in ethyl acetate, the solution was washed with water, then brine, dried (MgSO4) and stripped of solvent. The residue was recrystallized from ethyl acetate/petroleum ether to give 2-(7-chloro-2,3-dihydro-2-methyl-4-benzofuranyl)-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carboxylic acid (32D), as an amber solid, m.p.: 235°-236° C. (with decomposition).

Aufarbeitung

  1. temperatureat reflux temperature overnight
  2. stirringthe mixture was stirred
  3. temperatureat reflux temperature for 2 hours
  4. washthe solution was washed with water
  5. dry with materialbrine, dried (MgSO4)
  6. customThe residue was recrystallized from ethyl acetate/petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-9cd1a72c81b645a18bfe1485ff66021a
Quelldatensatz
uspto-grants-1990_08
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04948418

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion