Methylamine → 2,6-Dichloro-N-methylpyridin-4-amine

HRID 17096

Reaktionsgleichung

Reaktionsgleichung von HRID 17096
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[CH:5]=[C:4]([Cl:9])[N:3]=1.[CH3:10][NH2:11]>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([NH:11][CH3:10])[CH:5]=[C:4]([Cl:9])[N:3]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 27665Pyridine, 2,4,6-trichloro-

Produkt 1

HCID 199573942,6-Dichloro-N-methylpyridin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
22.5 °C

Versuchsvorschrift

2,4,6-Trichloropyridine (1800 g, 9.89 mol) was dissolved in ethanol (1800 mL). Methylamine 40% solution in ethanol (6.3 L) was added over 1 h and 40 min maintaining the reaction temperature between 20-25° C. The reaction was stirred for 14 hours at room temperature and concentrated. The product was filtered, washed with methyl t-butyl ether (1,500 ml) and dried to yield A1.6 (1200 g, 68%)

Aufarbeitung

  1. concentrationconcentrated
  2. filtrationThe product was filtered
  3. washwashed with methyl t-butyl ether (1,500 ml)
  4. customdried
  5. customto yield A1.6 (1200 g, 68%)

Quellen und Nachweise

ORD-Eintrag
ord-336a37a99c754ec081c44405c93b39d8
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737279B2

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