HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
p-Bromobenzenesulfonyl chloride → 4-bromo-N-(2-fluoro-4-methylphenyl)benzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | p-Bromobenzenesulfonyl chloride | HCID 7396 | — |
| Edukt | 2-Fluoro-4-methylaniline | HCID 67984 | — |
| Edukt | 1-((4-Bromophenyl)sulfonyl)azetidine | HCID 7213242 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Potassium Carbonate | HCID 11430 | — |
| Produkt | 4-bromo-N-(2-fluoro-4-methylphenyl)benzenesulfonamide | HCID 26979418 | — |
Reaktionsschritte
The title compound is analogously synthesized as described for 1-(4-bromo-benzenesulfonyl)-azetidine (compound C3) from 767 mg of 4-bromo-benzenesulfonyl chloride, 451 mg of commercially available 2-fluoro-4-methyl-aniline in 12.0 ml of dichloromethane and 6.0 ml of K2CO3 solution to yield 727 mg of the title compound as colorless, amorphous solid of m.p. 111° C. ESI-MS: 361.2/363.3 (MNH4+, 100%:87%). TLC: Rf=0.57 (neat dichloromethane).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07790710B2 |
| Quelldatensatz | uspto-grants-2010_09 |
| ORD ID | ord-1c6d1093e30144de95c330d34c3d33ee |
| Quellennotiz | uspto-grants-2010_09 |