Methyl iodide → HCID 178503338, Verbindung

HRID 1710808Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1710808
[CH3:1][I:2].[Cl:3][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]([CH3:15])[NH:7][C:8](=[S:14])[NH:9]2>CC(C)=O>[IH:2].[Cl:3][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]([CH3:15])[NH:7][C:8]([S:14][CH3:1])=[N:9]2

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 86609751HCID 86609751, Verbindung

Produkt 1

HCID 178503338HCID 178503338, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Methyl iodide (1.16 ml, 19 mmol) was added to a suspension of 5-chloro-4-methyl-3,4-dihydro-1H-quinazoline-2-thione (1.32 g, 6.2 mmol) in acetone (15 ml), and the mixture was stirred at r.t. over the weekend (the reaction is usually complete after 12 h). The precipitated product (2.08 g, 87%) was sufficiently pure for the next step.

Quellen und Nachweise

ORD-Eintrag
ord-cadcc21c206042fdaeddda56346e1729
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07790732B2

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