3-Chloro-4-nitrophenol → 4-(3-Chloro-4-nitrophenoxy)thieno[3,2-d]pyrimidine

HRID 1710967Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1710967
Cl[C:2]1[C:3]2[S:10][CH:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.FC1C=C([N+]([O-])=O)C=CC=1OC1C2SC(C(NCCN3CCOCC3)=O)=CC=2N=CN=1.[Cl:42][C:43]1[CH:44]=[C:45]([OH:52])[CH:46]=[CH:47][C:48]=1[N+:49]([O-:51])=[O:50]>>[Cl:42][C:43]1[CH:44]=[C:45]([CH:46]=[CH:47][C:48]=1[N+:49]([O-:51])=[O:50])[O:52][C:2]1[C:3]2[S:10][CH:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1

Komponenten

4

Edukt 3

HCID 102833-Chloro-4-nitrophenolHCID 27358214-Chlorothieno[3,2-d]pyrimidineHCID 594245534-(2-Fluoro-4-nitrophenoxy)-N-(2-morpholinoethyl)thieno[3,2-d]pyrimidine-6-carboxamide

Produkt 1

HCID 474463624-(3-Chloro-4-nitrophenoxy)thieno[3,2-d]pyrimidineAusbeute 72 %

Versuchsvorschrift

Starting from the chloride 20 (scheme 4) and following the procedure described above for the synthesis of compound 24 (scheme 4, example 22) replacing 2-fluoro-4-nitrophenol with 3-chloro-4-nitrophenol, title compound 171 was obtained in 72% yield. LRMS (M+1) 307.7 (100%).

Quellen und Nachweise

ORD-Eintrag
ord-5d7aff047d6748c78bcbac8c2df75f6d
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07790729B2

Notizen zur Reaktion

Wird geladen…