4,6-Dimethylpyrimidine-5-carboxylic acid → HCID 86629513, Verbindung

HRID 1711124Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1711124
[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([CH:11]([CH3:15])[CH2:12][CH2:13][NH2:14])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[CH3:16][C:17]1[C:22]([C:23](O)=[O:24])=[C:21]([CH3:26])[N:20]=[CH:19][N:18]=1>>[O:4]1[C:5]2([CH2:6][CH2:7][N:8]([CH:11]([CH3:15])[CH2:12][CH2:13][NH:14][C:23]([C:22]3[C:17]([CH3:16])=[N:18][CH:19]=[N:20][C:21]=3[CH3:26])=[O:24])[CH2:9][CH2:10]2)[O:1][CH2:2][CH2:3]1

Komponenten

3

Edukt 2

HCID 149222224,6-Dimethylpyrimidine-5-carboxylic acidHCID 687751013-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-butylamine

Produkt 1

HCID 86629513HCID 86629513, VerbindungAusbeute 73 %

Versuchsvorschrift

Using general procedure E with 3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butylamine (4.50 g, 21.0 mmol) and 4,6-dimethyl-pyrimidine-5-carboxylic acid (3.20 g, 21.0 mmol), followed by purification by column chromatography on silica gel (2-10% MeOH/CH2Cl2) gave 4,6-dimethyl-pyrimidine-5-carboxylic acid [3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butyl]-amide (5.10 g, 73%).

Aufarbeitung

  1. customfollowed by purification by column chromatography on silica gel (2-10% MeOH/CH2Cl2)

Quellen und Nachweise

ORD-Eintrag
ord-54851c9deba04fa4a1dd88b37390e727
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07790747B2

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