Hydrochloric Acid → 4-Morpholineacetic acid

HRID 1711129

Reaktionsgleichung

Reaktionsgleichung von HRID 1711129
C[O:2][C:3]([CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1)=[O:4].Cl>[OH-].[Na+].C1COCC1>[N:6]1([CH2:5][C:3]([OH:4])=[O:2])[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 1268178Methyl Morpholinoacetate

Produkt 1

HCID 4389684-Morpholineacetic acidAusbeute 90,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 20445995Sodium hydroxide tetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of methyl N-morpholinoacetate (0.85 g, 5.3 mmol) in 1:1 5N NaOH/THF (10 ml) was stirred at 50° C. for 1 h then neutralized to pH 3 with 6N HCl and concentrated. The yellowish solid was diluted with 1:1 MeOH/CH2Cl2 (25 ml), filtered to remove inorganic salts, and concentrated. The dilution, filtration and concentration were repeated to give morpholin-4-yl-acetic acid (695 mg, 90%) as a yellow solid.

Aufarbeitung

  1. concentrationconcentrated
  2. additionThe yellowish solid was diluted with 1:1 MeOH/CH2Cl2 (25 ml)
  3. filtrationfiltered
  4. customto remove inorganic salts
  5. concentrationconcentrated
  6. filtrationThe dilution, filtration and concentration

Quellen und Nachweise

ORD-Eintrag
ord-c839efddee6145ae97f0e0a9e044b0e9
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07790747B2

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