Trifluoroacetic acid → (R)-1-phenyl-N2-(tetrahydro-pyran-4-yl)-ethane-1,2-diamine TFA salt

HRID 1711189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1711189
C(OC(=O)[NH:7][C@H:8]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH2:9][NH:10][CH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)(C)(C)C.[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]>C(Cl)Cl>[OH:30][C:24]([C:26]([F:29])([F:28])[F:27])=[O:25].[C:17]1([C@@H:8]([NH2:7])[CH2:9][NH:10][CH:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68777024[(R)-1-phenyl-2-(tetrahydro-pyran-4-ylamino)-ethyl]-carbamic acid tert-butyl ester

Produkt 1

HCID 86629533(R)-1-phenyl-N2-(tetrahydro-pyran-4-yl)-ethane-1,2-diamine TFA salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of the tert-butyl carbamate (333 mg, 1.04 mmol) and TFA (1.0 ml) in CH2Cl2 (6.0 ml) was stirred at room temperature for 50 minutes. The excess solvent was removed under reduced pressure, giving the crude (R)-1-phenyl-N2-(tetrahydro-pyran-4-yl)-ethane-1,2-diamine TFA salt as a pale yellow oil (849 mg).

Aufarbeitung

  1. customThe excess solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-df56fd8f191b4e53924d355121229f7f
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07790747B2

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