2,4-Difluorophenol → HCID 58673064, Verbindung

HRID 1711738Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1711738
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[C:14]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:13]=[CH:12][C:11]=2[O:20][CH:21]([CH3:23])[CH3:22])=[O:9])[CH2:4][CH2:3]1.[F:24][C:25]1[CH:30]=[C:29]([F:31])[CH:28]=[CH:27][C:26]=1O>>[F:24][C:25]1[CH:30]=[C:29]([F:31])[CH:28]=[CH:27][C:26]=1[O:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]([C:10]2[CH:15]=[C:14]([S:16]([CH3:19])(=[O:18])=[O:17])[CH:13]=[CH:12][C:11]=2[O:20][CH:21]([CH3:23])[CH3:22])=[O:9])[CH2:6][CH2:7]1

Komponenten

3

Edukt 2

HCID 1230512,4-DifluorophenolHCID 58673083(4-Hydroxy-piperidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

Produkt 1

HCID 58673064HCID 58673064, VerbindungAusbeute 21 %

Versuchsvorschrift

Prepared in analogy to Example 4 from (4-hydroxy-piperidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone (Example 3(a)) and 2,4-difluorophenol. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 21%). MS (m/e): 454.3 (M+H+, 100%).

Aufarbeitung

  1. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)

Quellen und Nachweise

ORD-Eintrag
ord-91a4ca6b8d8e4e8da7864ea2dd51ccf0
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07790763B2

Notizen zur Reaktion

Wird geladen…