2-Fluoro-4-nitrophenol → Rac-[3-(2-fluoro-4-nitro-phenoxy)-pyrrolidin-1-yl]-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

HRID 1711745Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1711745
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:14]=[C:13]([S:15]([CH3:18])(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=2[O:19][CH:20]([CH3:22])[CH3:21])=[O:8])[CH2:3]1.[F:23][C:24]1[CH:29]=[C:28]([N+:30]([O-:32])=[O:31])[CH:27]=[CH:26][C:25]=1O>>[F:23][C:24]1[CH:29]=[C:28]([N+:30]([O-:32])=[O:31])[CH:27]=[CH:26][C:25]=1[O:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:14]=[C:13]([S:15]([CH3:18])(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=2[O:19][CH:20]([CH3:22])[CH3:21])=[O:8])[CH2:3]1

Komponenten

3

Edukt 2

HCID 98252-Fluoro-4-nitrophenolHCID 58673070Rac-(3-hydroxy-pyrrolidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

Produkt 1

HCID 58673062Rac-[3-(2-fluoro-4-nitro-phenoxy)-pyrrolidin-1-yl]-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanoneAusbeute 23 %

Versuchsvorschrift

Prepared in analogy to Example 4 from rac-(3-hydroxy-pyrrolidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone (Example 9(a)) and 2-fluoro-4-nitrophenol. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 23%). MS (m/e): 467.4 (M+H+, 100%).

Aufarbeitung

  1. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)

Quellen und Nachweise

ORD-Eintrag
ord-abe17297d911440298426bd12c14a4fc
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07790763B2

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