2-Naphthol → Rac-(2-isopropoxy-5-methanesulfonyl-phenyl)-[3-(naphthalen-2-yloxy)-pyrrolidin-1-yl]-methanone

HRID 1711752Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1711752
[CH:1]([O:4][C:5]1[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][C:6]=1[C:7]([N:9]1[CH2:13][CH2:12][CH:11]([O:14]S(C)(=O)=O)[CH2:10]1)=[O:8])([CH3:3])[CH3:2].[CH:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][C:28]=1O>>[CH:1]([O:4][C:5]1[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][C:6]=1[C:7]([N:9]1[CH2:13][CH2:12][CH:11]([O:14][C:29]2[CH:28]=[CH:27][C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]=2)[CH2:10]1)=[O:8])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 86632-NaphtholHCID 58673069Rac-Methanesulfonic acid 1-(2-isopropoxy-5-methanesulfonyl-benzoyl)-pyrrolidin-3-yl ester

Produkt 1

HCID 11539733Rac-(2-isopropoxy-5-methanesulfonyl-phenyl)-[3-(naphthalen-2-yloxy)-pyrrolidin-1-yl]-methanoneAusbeute 40 %

Versuchsvorschrift

Prepared in analogy to Example 3(c) from rac-methanesulfonic acid 1-(2-isopropoxy-5-methanesulfonyl-benzoyl)-pyrrolidin-3-yl ester (Example 14(a)) and 2-naphthol. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous yellow solid (yield 40%). MS (m/e): 454.5 (M+H+, 100%).

Aufarbeitung

  1. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)

Quellen und Nachweise

ORD-Eintrag
ord-ef834a05377f4ef292f682181d8dcb6c
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07790763B2

Notizen zur Reaktion

Wird geladen…