1-Fluoro-3,5-dimethyl-2-nitrobenzene → HCID 56637722, Verbindung
Reaktionsgleichung
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:13][NH:14][C:15]1[CH:20]=[C:19]([CH3:21])[CH:18]=[C:17]([CH3:22])[C:16]=1[N+:23]([O-])=O)[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].C[O:27][C:28](=[O:50])[CH2:29]N1C2C=CC=CC=2NC[C@H](NC(OC(C)(C)C)=O)C1=O.F[C:52]1[CH:57]=[C:56](C)[CH:55]=[C:54]([CH3:59])[C:53]=1[N+]([O-])=O>>[CH2:59]([O:50][C:28](=[O:27])[CH2:29][N:23]1[C:16]2[C:17]([CH3:22])=[CH:18][C:19]([CH3:21])=[CH:20][C:15]=2[NH:14][CH2:13][C@H:9]([NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[C:10]1=[O:12])[C:54]1[CH:53]=[CH:52][CH:57]=[CH:56][CH:55]=1Komponenten
4
Versuchsvorschrift
(2S)-2-tert-Butoxycarbonylamino-3-(2-nitro-3,5-dimethylphenylamino)-propionic acid. Prepared by a method similar as described for 600a/103 (Step A), except 2-fluoro-4,6-dimethyl-nitrobenzene was used instead of 2-fluoronitrobenzene to give the desired compound in 93% yield.