Allyl bromide → HCID 68501175, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:32]=[CH:31][CH:30]=[CH:29][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH:16]2[OH:28])=[CH:11][CH:10]=1.[CH2:33](Br)[CH:34]=[CH2:35]>>[CH2:35]([O:28][CH:16]1[CH:15]([C:12]2[CH:11]=[CH:10][C:9]([O:8][CH2:7][CH2:6][CH2:5][O:4][C:3]3[CH:29]=[CH:30][CH:31]=[CH:32][C:2]=3[Cl:1])=[CH:14][CH:13]=2)[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17]1)[CH:34]=[CH2:33]Komponenten
3
Versuchsvorschrift
Analogously to Method D, 2.01 g of tert-butyl 4-{4-[3-(2-chlorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate and 0.74 ml of allylbromide are reacted. The title compound is obtained as a colourless oil. Rf=0.80 (1:1 EtOAc-heptane); Rt=6.13.
Quellen und Nachweise
- ORD-Eintrag
- ord-684a4ced64b14f53ab263aa725ef1e02
- Quelldatensatz
- uspto-grants-2010_09
- Patentnummer
- US07790715B2
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