Trifluoroacetic acid → 3-(Hydroxymethyl)azetidine trifluoroacetate

HRID 1712650Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1712650
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[OH:8][CH2:9][CH:10]1[CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[OH:8][CH2:9][CH:10]1[CH2:13][NH:12][CH2:11]1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 10583745tert-Butyl 3-(hydroxymethyl)azetidine-1-carboxylate

Produkt 1

HCID 685001703-(Hydroxymethyl)azetidine trifluoroacetate

Versuchsvorschrift

Trifluoroacetic acid (0.413 ml) was added to tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate (125 mg) with cooling in an ice bath, followed by stirring at the same temperature for 30 minutes. Then the reaction mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated to give a crude product of the title compound (209.8 mg) as a yellow oil.

Aufarbeitung

  1. temperaturewith cooling in an ice bath
  2. stirringThen the reaction mixture was stirred at room temperature for 1.5 hours
  3. concentrationThe reaction mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-a3848cf7b5da400ea19765646c790181
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07790885B2

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