Hydrochloric Acid → 2,2-Difluorocyclohexan-1-amine--hydrogen chloride (1/1)
Reaktionsgleichung
[F:1][C:2]1([F:19])[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[NH:8]C(=O)OCC1C=CC=CC=1.[ClH:20]>>[ClH:20].[F:1][C:2]1([F:19])[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[NH2:8]Komponenten
3
Versuchsvorschrift
A solution of benzyl 2,2-difluorocyclohexylcarbamate (38 mg, 0.14 mmol) in 6 N HCl (2 mL) was heated at 100° C. for 2 h. The cooled reaction mixture was extracted with ether (3×1 mL) and the combined organic layers were concentrated to give 2,2-difluorocyclohexanamine hydrochloride as a light brown solid (23 mg, 96% crude).
Aufarbeitung
- customThe cooled reaction mixture
- extractionwas extracted with ether (3×1 mL)
- concentrationthe combined organic layers were concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-d62d1e0025614c6d9b19651e946733dc
- Quelldatensatz
- uspto-grants-2010_09
- Patentnummer
- US07790770B2
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