Potassium Carbonate → 4-[2-(4-Nitro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-butyronitrile

HRID 1713044

Reaktionsgleichung

Reaktionsgleichung von HRID 1713044
C([O:3][C:4]([C:6]1[NH:10][C:9]2[CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)[O:13][C:8]=2[CH:7]=1)=O)C.C(OC(=O)C(CC)CCN1C(=S)N2C3C=C(C4C=CC([N+]([O-])=O)=CC=4)OC=3C=C2C1=O)C.[N:55]([CH2:58][CH2:59][CH2:60][C:61]#[N:62])=[C:56]=[S:57].C([O-])([O-])=O.[K+].[K+]>C(O)C>[N+:20]([C:17]1[CH:16]=[CH:15][C:14]([C:12]2[O:13][C:8]3[CH:7]=[C:6]4[C:4](=[O:3])[N:55]([CH2:58][CH2:59][CH2:60][C:61]#[N:62])[C:56](=[S:57])[N:10]4[C:9]=3[CH:11]=2)=[CH:19][CH:18]=1)([O-:22])=[O:21]

Komponenten

6

Edukt 4

HCID 11430Potassium CarbonateHCID 151346444-Isothiocyanato-butyronitrileHCID 594634452-(4-nitro-phenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl esterHCID 86618327HCID 86618327, Verbindung

Produkt 1

HCID 116537784-[2-(4-Nitro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-butyronitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

2-(4-nitro-phenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester (60.97 mg, 0.21 mmol), prepared as described hereinabove (see, preparation of Compound 1), 4-isothiocyanato-butyronitrile (664 mg, 2.1 mmol) and a fine powder of anhydrous K2CO3 (27.6 mg, 0.2 mmol) are mixed together in a sealed tube, provided with a magnetic stirrer, and the mixture is heated at 110° C. for 2 hours. The mixture is cooled to room temperature, ethanol is added (2 ml), and the formed precipitate is filtered. The crude product is recrystallized from ethanol to give Compound 35.

Aufarbeitung

  1. customprovided with a magnetic stirrer
  2. temperatureThe mixture is cooled to room temperature
  3. filtrationthe formed precipitate is filtered
  4. customThe crude product is recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f7bf6337c3444f61a0f6334556d517b1
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07795255B2

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