Ammonia → [4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-urea

Beteiligte Stoffe

Reaktionsschritte

A mixture of 1-[2-(4-isothiocyanato-phenoxy)-ethyl]-pyrrolidine (0.355 g, 1.43 mmol), MeOH (2.75 mL) and a 2M solution of NH3 in MeOH (2.75 mL, 5.49 mmol, 3.84 equiv) is heated in a sealed tube at 60° C. for 1 h, under an argon atmosphere. The reaction mixture is allowed to cool to RT and concentrated in vacuo to afford the title compound as a dark brown solid: ES-MS: 266.0 [M+H]+; single peak at tR=3.99 min (System 1).

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