3-amino-N,N-dimethylbenzylamine → HCID 18621787, Verbindung

HRID 1713635Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1713635
[N:1]1(CCOC2C=CC(NC(N)=O)=CC=2)CCCC1.[N:19]([C:22]1[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=1)[CH2:25][N:26]([CH3:28])[CH3:27])=[C:20]=[S:21].N(C1C=CC(OCCN2CCCC2)=CC=1)=C=S.CN(CC1C=C(N)C=CC=1)C>C(Cl)Cl.CO>[CH3:27][N:26]([CH2:25][C:24]1[CH:23]=[C:22]([NH:19][C:20]([NH2:1])=[S:21])[CH:31]=[CH:30][CH:29]=1)[CH3:28].[N:19]([C:22]1[CH:23]=[C:24]([CH:29]=[CH:30][CH:31]=1)[CH2:25][N:26]([CH3:28])[CH3:27])=[C:20]=[S:21]

Komponenten

7

Edukt 4

HCID 992943-amino-N,N-dimethylbenzylamineHCID 118461221-(2-(4-Isothiocyanatophenoxy)ethyl)pyrrolidineHCID 59689650HCID 59689650, VerbindungHCID 68704441[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-urea

Produkt 2

HCID 18621787HCID 18621787, VerbindungHCID 59689650HCID 59689650, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21226129Dichloromethane methanolLösungsmittel

Versuchsvorschrift

The title compound is prepared as described in Example 1 for [4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-urea but using (3-isothiocyanato-benzyl)-dimethyl-amine. Title compound: ES-MS: 210.0 [M+H]+; single peak at tR=3.38 min (System 1); Rf=0.63 (CH2Cl2/MeOH, 80/20). (3-Isothiocyanato-benzyl)-dimethyl-amine is prepared as described in Example 1 for 1-[2-(4-isothiocyanato-phenoxy)ethyl]-pyrrolidine but using 3-dimethylaminomethyl-phenylamine. (3-Isothiocyanato-benzyl)dimethyl-amine is obtained and used as an impure crude material.

Aufarbeitung

  1. customThe title compound is prepared
  2. custom(3-Isothiocyanato-benzyl)-dimethyl-amine is prepared

Quellen und Nachweise

ORD-Eintrag
ord-cda9356e9d114220b1e49b432a91ff9d
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07795288B2

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