1-(4-Isothiocyanatophenyl)-4-methylpiperazine → [4-(4-Methylpiperazin-1-yl)phenyl]thiourea

HRID 1713640Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1713640
[N:1]1(CCOC2C=CC(NC(N)=O)=CC=2)CCCC1.[N:19]([C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]2)=[CH:24][CH:23]=1)=[C:20]=[S:21]>C(Cl)Cl.CO>[CH3:34][N:31]1[CH2:30][CH2:29][N:28]([C:25]2[CH:24]=[CH:23][C:22]([NH:19][C:20]([NH2:1])=[S:21])=[CH:27][CH:26]=2)[CH2:33][CH2:32]1

Komponenten

4

Edukt 2

HCID 137183971-(4-Isothiocyanatophenyl)-4-methylpiperazineHCID 68704441[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-urea

Produkt 1

HCID 39146979[4-(4-Methylpiperazin-1-yl)phenyl]thiourea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21226129Dichloromethane methanolLösungsmittel

Versuchsvorschrift

The title compound is prepared as described in Example 1 for [4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-urea but using 1-(4-isothiocyanato-phenyl)-4-methyl-piperazine and stirring the reaction mixture at RT for 17 h. Title compound: ES-MS: 251.0 [M+H]+; major peak at tR=3.56 min (System 1); Rf=0.27 (CH2Cl2/MeOH, 80/20).

Aufarbeitung

  1. customThe title compound is prepared

Quellen und Nachweise

ORD-Eintrag
ord-746305e35e8f487e818aa19cb3104da5
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07795288B2

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