Ethylene carbonate → 2-(2,6-Dichloro-4-methylphenoxy)ethan-1-ol

HRID 1715388

Reaktionsgleichung

Reaktionsgleichung von HRID 1715388
[Cl:1][C:2]1[C:7]([OH:8])=[C:6]([Cl:9])[CH:5]=[C:4]([CH3:10])[CH:3]=1.[O:11]1[CH2:15][CH2:14]OC1=O>N1C=CN=C1>[Cl:1][C:2]1[CH:3]=[C:4]([CH3:10])[CH:5]=[C:6]([Cl:9])[C:7]=1[O:8][CH2:14][CH2:15][OH:11]

Komponenten

4

Edukt 2

HCID 7303Ethylene carbonateHCID 170772,6-Dichloro-4-methylphenol

Produkt 1

HCID 213969022-(2,6-Dichloro-4-methylphenoxy)ethan-1-olAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 795ImidazoleKatalysator

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

In a three-necked flask equipped with a gas droplet counter and an efficient cooling system, a mixture of 2,6-dichloro-p-cresol (20.0 g, 113 mmol), [1,3]dioxolan-2-one (9.95 g, 113 mmol) and imidazole (115 mg, 1.70 mmol) was heated to 160° C. for 25 h. The mixture was allowed to cool to rt. Purification by FC (Et2O/heptane 1.1) yielded the title compound (18.7 g, 75%). LC-MS: tR=0.88 min.

Aufarbeitung

  1. customIn a three-necked flask equipped with a gas droplet counter
  2. temperatureto cool to rt
  3. customPurification by FC (Et2O/heptane 1.1)

Quellen und Nachweise

ORD-Eintrag
ord-4dc2c97d68f44f4081e8721cddef7203
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07799805B2

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