HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetone → Acetoacetic Acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetone | HCID 180 | — |
| Edukt | Tert-butyl 4-{4-amino-7-[(1e)-3-(diethylamino)-1-propenyl]thieno[3,2-c]pyridin-3-yl}-2-methoxyphenylcarbamate | HCID 18451456 | — |
| Lösungsmittel | Hydrochloric Acid | HCID 313 | — |
| Produkt | Acetoacetic Acid | HCID 96 | — |
| Produkt | 3-(4-Amino-3-methoxyphenyl)-7-[(1e)-3-(diethylamino)-1-propenyl]thieno[3,2-c]pyridin-4-amine | HCID 18450708 | — |
Reaktionsschritte
A mixture of Example 365B (425 mg, 0.88 mmol) in acetone (10 mL) and 6N aqueous hydrochloric acid (2 mL) was stirred for 18 hours at ambient temperature then concentrated under reduced pressure. The residue was then purified by preparative reverse phase HPLC to provide the desired product as the diacetate salt. 1H NMR (DMSO-d6, 400 MHz) δ 7.89 (s, 1H), 7.39 (s, 1H), 6.82 (s, 1H), 6.73 (s, 2H), 6.20 (m, 1H), 5.65 (br s, 2H), 3.78 (s, 3H), 3.30 (d, 2H), 2.56 (q, 4H), 1.88 (s, 6H), 1.01 (t, 6H); MS m/e 383.4 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07737160B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-367b7d43e9bc41959719091afb7378aa |
| Quellennotiz | uspto-grants-2010_06 |