4-Fluorobenzenesulfonyl chloride → N-(2-Bromo-pyridin-3-yl)-4-fluoro-benzenesulfonamide

HRID 1716281Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1716281
[NH2:1][C:2]1[C:3]([Br:8])=[N:4][CH:5]=[CH:6][CH:7]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1>ClCCl.N1C=CC=CC=1>[Br:8][C:3]1[C:2]([NH:1][S:16]([C:13]2[CH:14]=[CH:15][C:10]([F:9])=[CH:11][CH:12]=2)(=[O:18])=[O:17])=[CH:7][CH:6]=[CH:5][N:4]=1

Komponenten

5

Edukt 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 6428163-Amino-2-bromopyridine

Produkt 1

HCID 86619934N-(2-Bromo-pyridin-3-yl)-4-fluoro-benzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of 3-amino-2-bromo-pyridine (0.4 g, 2.3 mmol) in dichloromethane (4 ml) and pyridine (4 ml) was added 4-fluoro-benzenesulfonylchloride (0.45 g, 2.3 mmol) in one portion. The mixture was stirred overnight. The mixture was diluted with dichloromethane and washed with saturated NaCl solution. The organic layer was dried over sodium sulfate and concentrated. The crude product was purified through chromatography (2-5% EtOAc in dichloromethane). MS 331.8 (M+H)+

Aufarbeitung

  1. washwashed with saturated NaCl solution
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. concentrationconcentrated
  4. customThe crude product was purified through chromatography (2-5% EtOAc in dichloromethane)

Quellen und Nachweise

ORD-Eintrag
ord-7835a80f5e544a4eaccc53c5708fcdb0
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07803793B2

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