3-Benzyloxy-1-(toluene-4-sulfonylmethyl)-1H-pyridin-2-one → 3-Hydroxy-1-(toluene-4-sulfonylmethyl)-1h-pyridin-2-one

HRID 1716306Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1716306
C([O:8][C:9]1[C:10](=[O:26])[N:11]([CH2:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CS(O)(=O)=O>[OH:8][C:9]1[C:10](=[O:26])[N:11]([CH2:15][S:16]([C:19]2[CH:20]=[CH:21][C:22]([CH3:25])=[CH:23][CH:24]=2)(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1

Komponenten

3

Edukt 1

HCID 685103983-Benzyloxy-1-(toluene-4-sulfonylmethyl)-1H-pyridin-2-one

Produkt 1

HCID 444558373-Hydroxy-1-(toluene-4-sulfonylmethyl)-1h-pyridin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6395Methanesulfonic AcidLösungsmittel

Versuchsvorschrift

A solution of 3-benzyloxy-1-(toluene-4-sulfonylmethyl)-1H-pyridin-2-one (50 mg) from Step B in MeSO3H (1.5 mL) was stirred at room temperature for 20 min and then quenched with ice water. The solid was filtered off and washed with water. The crude product was re-dissolved in hot MeOH (1 mL) and removed un-dissolved brownish solid. The filtrate was concentrated in vacuo to give the titled compound. MS (EI) 280 (M+H)+.

Aufarbeitung

  1. customquenched with ice water
  2. filtrationThe solid was filtered off
  3. washwashed with water
  4. dissolutionThe crude product was re-dissolved in hot MeOH (1 mL)
  5. customremoved
  6. dissolutionun-dissolved brownish solid
  7. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-769f85478d454fe49c95ee592e78da34
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07803793B2

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