Methylorthoformate → 6-fluoro-5-methyl-1-piperidin-4-yl-1H-benzoimidazole

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 4-(2-amino-5-fluoro-4-methyl-phenylamino)piperidine-1-carboxylic acid tert-butyl ester (250 mg, 0.309 mmol) in formic acid (3 mL) was added methyl orthoformate (0.5 mL). After heating for 3 hours at 60° C., the volatiles was removed under reduced pressure to afford crude product 6-fluoro-5-methyl-1-piperidin-4-yl-1H-benzoimidazole (180 mg, 99%) as a brown solid.

Herkunft & Nachweise