2,6-Diaminopyridine → N-(6-Aminopyridin-2-yl)-2,6-difluorobenzamide

Beteiligte Stoffe

Reaktionsschritte

Using a method similar to Preparation 48, using 2,6-diaminopyridine (2.6 g, 24 mmol), dioxane (75 mL), and 2,6-difluorobenzoyl chloride (1.4 g, 8 mmol) (stir at 25° C. for 16 hr.), gives the title intermediate (1.5 g, 75% yield): mass spectrum (ion spray): m/z=250.1 (M+1).

Herkunft & Nachweise