2-phenyl-1H-imidazole-4-carboxylic acid → {3-[(2-phenyl-1H-imidazole-5-carbonyl)-amino]-phenyl}acetic acid ethyl ester
Reaktionsgleichung
[C:1]1([C:7]2[NH:8][C:9]([C:12]([OH:14])=O)=[CH:10][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:15]([O:17][C:18](=[O:27])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH2:26])[CH:21]=1)[CH3:16]>>[CH2:15]([O:17][C:18](=[O:27])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][C:12]([C:9]2[NH:8][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[N:11][CH:10]=2)=[O:14])[CH:21]=1)[CH3:16]Komponenten
3
Versuchsvorschrift
2-Phenyl-1H-imidazole-5-carboxylic acid (105 mg, 0.56 mmol) was coupled with ethyl ester (6) (100 mg, 0.56 mmol) following Method C to give the title compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-43a70a5315b6415892c7f6389a881e9f
- Quelldatensatz
- uspto-grants-2010_09