Ethyl 2-(3-aminophenoxy)acetate → (3-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-phenoxy)-acetic acid ethyl ester

HRID 1717054Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1717054
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:16]([O:18][C:19](=[O:29])[CH2:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([NH2:28])[CH:23]=1)[CH3:17]>>[CH2:16]([O:18][C:19](=[O:29])[CH2:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][C:13]([C:11]2[O:12][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)=[CH:9][CH:10]=2)=[O:15])[CH:23]=1)[CH3:17]

Komponenten

3

Edukt 2

HCID 412308Ethyl 2-(3-aminophenoxy)acetateHCID 7362565-(3-Chlorophenyl)furan-2-carboxylic acid

Produkt 1

HCID 59654640(3-{[5-(3-Chloro-phenyl)-furan-2-carbonyl]-amino}-phenoxy)-acetic acid ethyl ester

Versuchsvorschrift

Carboxylic acid (65) (67 mg, 0.3 mmol) was coupled to ethyl ester (64) (58 mg, 0.25 mmol) using Method C. The crude residue was purified by column chromatography eluting with a stepped gradient of 10-20% EtOAc in heptane to give the title compound.

Aufarbeitung

  1. customThe crude residue was purified by column chromatography
  2. washeluting with a stepped gradient of 10-20% EtOAc in heptane

Quellen und Nachweise

ORD-Eintrag
ord-109959d1722b44e3b6aaa512fe9840b4
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07803841B2

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