Formaldehyde → 1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-4-hydroxymethyl-pyrazolidine-3,5-dione

HRID 1719691Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1719691
[CH2:1]=[O:2].[C:3]1([N:9]2[C:13](=[O:14])[CH:12]([CH2:15][CH2:16][S:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[O:18])[C:11](=[O:25])[N:10]2[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CO>[C:26]1([N:10]2[C:11](=[O:25])[C:12]([CH2:15][CH2:16][S:17]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[O:18])([CH2:1][OH:2])[C:13](=[O:14])[N:9]2[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Komponenten

4

Edukt 2

HCID 712FormaldehydeHCID 5342Sulfinpyrazone

Produkt 1

HCID 202664801,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-4-hydroxymethyl-pyrazolidine-3,5-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

40% Formaline (25 ml) is added to a solution of 20 grams of 1,2-diphenyl-4-[2-(phenylsulfinyl)-ethyl]-pyrazolidine-3,5-dione in 120 ml of methanol. The solution, under magnetic stirring, is heated up to 50° C. for one hour and kept, always under a magnetic stirring, at room temperature for 12 hours. At the end the solvent is evaporated under reduced pressure, the residue is washed with water and extracted with dichloromethane.

Aufarbeitung

  1. customAt the end the solvent is evaporated under reduced pressure
  2. washthe residue is washed with water
  3. extractionextracted with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-deb660bfe1394394b7490124f25e7769
Quelldatensatz
uspto-grants-1985_09
Patentnummer
US04542141

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