Ammonia → Tert-butyl 2-(aminomethyl)-2-ethylbutanoate

HRID 1720335Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1720335
[C:1]([O:5][C:6](=[O:14])[C:7]([C:12]#[N:13])([CH2:10][CH3:11])[CH2:8][CH3:9])([CH3:4])([CH3:3])[CH3:2].N>C(O)C.[Ni]>[C:1]([O:5][C:6](=[O:14])[C:7]([CH2:12][NH2:13])([CH2:10][CH3:11])[CH2:8][CH3:9])([CH3:2])([CH3:4])[CH3:3]

Komponenten

5

Edukt 2

HCID 222AmmoniaHCID 54237674Tert-butyl 2-cyano-2-ethylbutanoate

Produkt 1

HCID 54399069Tert-butyl 2-(aminomethyl)-2-ethylbutanoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

29.21 g of 2-cyano-2-ethylbutyric acid tert-butyl ester, dissolved in 300 ml of ethanol, which contains 4% ammonia, are hydrogenated under normal pressure at 40° in the presence of 6 g of Raney nickel. After separating off from the catalyst, the batch is concentrated by evaporation in vacuo and the liquid that remains is distilled in vacuo to yield 2-aminomethyl-2-ethylbutyric acid tert-butyl ester, boiling point 65° at 0.6 mbar.

Aufarbeitung

  1. customAfter separating off from the catalyst
  2. concentrationthe batch is concentrated by evaporation in vacuo
  3. distillationthe liquid that remains is distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3b1757af0686452099323989689ba767
Quelldatensatz
uspto-grants-1996_04
Patentnummer
US05506240

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