HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzyloxyamine hydrochloride → N-Benzyloxy-2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzyloxyamine hydrochloride | HCID 102312 | — |
| Edukt | O-tert-butylhydroxylamine hydrochloride | HCID 2777906 | — |
| Edukt | 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methyl-butanoic acid hydrochloride | HCID 70061703 | — |
| Produkt | N-Benzyloxy-2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanamide | HCID 22856293 | — |
Reaktionsschritte
The N-(benzyloxy) substituted prodrug derivative of the above compound is prepared as follows: 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanoic acid hydrochloride is reacted with O-benzylhydroxylamine hydrochloride under conditions described for reaction with O-t-butylhydroxylamine hydrochloride to yield N-(benzyloxy)-2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methyl-butanamide, m.p. 74.5°-76° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05506242 |
| Quelldatensatz | uspto-grants-1996_04 |
| ORD ID | ord-a8ab2795d56941fabd1c2e776924aa98 |
| Quellennotiz | uspto-grants-1996_04 |