Ethanol → 1-(Benzothiophen-2-yl)piperazine
Reaktionsgleichung
Cl[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:11]1[CH2:16][CH2:15]N[CH2:13][CH2:12]1.[CH2:17](O)C>>[S:3]1[C:2]([N:6]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[CH:17][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]1=2Komponenten
4
Versuchsvorschrift
2-Chlorobenzothiazole (5 g) is heated in ethanol (75 ml) with piperazine (3.05 g) for 20 h. The mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate. The organic phase is separated, dried with sodium sulfate and concentrated to give the title compound.
Aufarbeitung
- customThe mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate
- customThe organic phase is separated
- dry with materialdried with sodium sulfate
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-a8d0340aa6a74d068b2afab42c4d13a2
- Quelldatensatz
- uspto-grants-1996_04
- Patentnummer
- US05506354
Notizen zur Reaktion
Wird geladen…