Trifluoroacetic acid → (4-(6,7-Bis(stearyloxy)-4-thiaheptanoylamino)benzoyl)glutamic acid

HRID 1720819

Reaktionsgleichung

Reaktionsgleichung von HRID 1720819
C([O:5][C:6](=[O:73])[C@H:7]([CH2:64][CH2:65][C:66]([O:68]C(C)(C)C)=[O:67])[NH:8][C:9](=[O:63])[C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:62])[CH2:18][CH2:19][S:20][CH2:21][CH:22]([O:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH3:61])[CH2:23][O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])=[CH:12][CH:11]=1)(C)(C)C.FC(F)(F)C(O)=O>>[CH2:44]([O:43][CH:22]([CH2:23][O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:21][S:20][CH2:19][CH2:18][C:17]([NH:16][C:13]1[CH:12]=[CH:11][C:10]([C:9]([NH:8][C@H:7]([C:6]([OH:73])=[O:5])[CH2:64][CH2:65][C:66]([OH:68])=[O:67])=[O:63])=[CH:15][CH:14]=1)=[O:62])[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH3:61]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 53695392(4-(6,7-Bis(stearyloxy)-4-thiaheptanoylamino)benzoyl)glutamic acid di-t-butyl ester

Produkt 1

HCID 53849118(4-(6,7-Bis(stearyloxy)-4-thiaheptanoylamino)benzoyl)glutamic acidAusbeute 94 %

Versuchsvorschrift

To (4-(6,7-bis(stearyloxy)-4-thiaheptanoylamino)benzoyl)glutamic acid di-t-butyl ester as obtained in Example 25 (75 mg), trifiuoroacetic acid (5 ml) was added, followed by stirring at room temperature for 24 hours. The mixture was concentrated to yield the title compound (64 mg, yield 94%) as a colorless crystal.

Aufarbeitung

  1. additionwas added
  2. concentrationThe mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-cb20f8d6a0614b1ab398eb740a8b5431
Quelldatensatz
uspto-grants-1996_04
Patentnummer
US05506267

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