Triethylamine → HCID 178418448, Verbindung

HRID 1721

Reaktionsgleichung

Reaktionsgleichung von HRID 1721
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([OH:20])=[CH:14][C:15](=[O:19])[O:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.C1(C)C=CC(S([N:37]=[N+:38]=[N-])(=O)=O)=CC=1>C1COCC1>[N+:37](=[C:14]1[C:13](=[O:20])[C:12]2[C:17](=[CH:18][C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:10][CH:11]=2)[O:16][C:15]1=[O:19])=[N-:38]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 13661p-Toluenesulfonyl azideHCID 547084427-(Benzyloxy)-4-hydroxy-2H-1-benzopyran-2-one

Produkt 1

HCID 178418448HCID 178418448, VerbindungAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A solution of 7-benzyloxy -4-hydroxy coumarin (2.5 g, 9.3 mmol; prepared in accordance with Example 5) in anhydrous THF (40 mL) was mixed with triethylamine (0.9 g, 9 mmol) taken in a 100 mL 3-neck round-bottom flask under an atmosphere of N2. A solution of p-toluenesulfonyl azide (2.8 g, 14 mmol) in dry THF (20 mL) was added dropwise through an addition funnel. The mixture was stirred at room temperature for 3 hrs. The color of the solution turned orange. The solvent was rotary evaporated and the product was taken in CH2Cl2 and washed with water (3 times). Petroleum ether (twice the volume) was added to the solution and the solid precipitate was filtered with a flit and dried at 45° C. The product was recrystallized using CH2Cl2 ; yield 90%. The product was characterized by NMR: 13C NMR (100 MHz, CD2 Cl2): 173.3, 165.4, 158.7, 156.0, 136.0, 129.1, 128.8, 128.0, 127.6, 113.9, 113.0, 103.0, 75.7, 71.2; DSC--m. pt. 191° C. followed by decomposition; IR (KBr): 2182, 2154, 1717, 1647, 1605 cm-1 ; MS(APCI): (M+H), 295 (base peak).

Aufarbeitung

  1. customtaken in a 100 mL 3-neck round-bottom flask under an atmosphere of N2
  2. customThe solvent was rotary evaporated
  3. washwashed with water (3 times)
  4. additionPetroleum ether (twice the volume) was added to the solution
  5. filtrationthe solid precipitate was filtered with a flit
  6. customdried at 45° C
  7. customThe product was recrystallized

Quellen und Nachweise

ORD-Eintrag
ord-eafe799634bf413884245083d524cea5
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05726295

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