Chloroacetyl chloride → 1-(2-Chloroacetyl)-4-(2,3,4,5,6-pentafluorophenoxy)-4-phenylpiperidine

HRID 1721861Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1721861
[F:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[C:18]([F:23])=[C:17]([F:24])[C:3]=1[O:4][C:5]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1.C(N(CC)CC)C.[Cl:32][CH2:33][C:34](Cl)=[O:35]>ClCCl.C(OCC)(=O)C>[Cl:32][CH2:33][C:34]([N:8]1[CH2:7][CH2:6][C:5]([O:4][C:3]2[C:17]([F:24])=[C:18]([F:23])[C:19]([F:22])=[C:20]([F:21])[C:2]=2[F:1])([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:10][CH2:9]1)=[O:35]

Komponenten

6

Edukt 3

HCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 146499784-(2,3,4,5,6-Pentafluorophenoxy)-4-phenylpiperidine

Produkt 1

HCID 146499821-(2-Chloroacetyl)-4-(2,3,4,5,6-pentafluorophenoxy)-4-phenylpiperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittel2×HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A chilled solution of 4.0 g of 4-(2,3,4,5,6-pentafluorophenoxy)-4-phenylpiperidine and 2.4 ml of triethylamine in 50 ml of dichloromethane was treated with a solution of 1.4 ml of chloroacetyl chloride in 10 ml of dichloromethane and then stirred at ambient temperature for four hours. The mixture was diluted with 100 ml of ethyl acetate, dried over anhydrous magnesium sulfate, filtered and evaporated to yield 5.0 g of 1-(2-chloroacetyl)-4-(2,3,4,5,6-pentafluorophenoxy)-4-phenylpiperidine as an oil.

Aufarbeitung

  1. dry with materialdried over anhydrous magnesium sulfate
  2. filtrationfiltered
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-0bb438774a1942aebe53a34a253b8c70
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04853384

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