Potassium Carbonate → Ethyl-2-(2-propylimidazol-1-yl)propanoate

HRID 1721885Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1721885
[CH2:1]([C:4]1[NH:5][CH:6]=[CH:7][N:8]=1)[CH2:2][CH3:3].Br[CH:10]([CH3:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:14]([O:13][C:11](=[O:12])[CH:10]([N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[CH2:1][CH2:2][CH3:3])[CH3:16])[CH3:15]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 79040Ethyl 2-bromopropionateHCID 1626172-Propylimidazole

Produkt 1

HCID 20070368Ethyl-2-(2-propylimidazol-1-yl)propanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

2-Propylimidazole (5.5 g), ethyl 2-bromopropionate (9.95 g) and potassium carbonate (12.4 g) were stirred in refluxing acetonitrile (100 ml) for 72 hours. The suspension was allowed to cool, filtered and the solvent removed under reduced pressure, yielding the title compound as an off-white foam, 9.2 g [88%].

Aufarbeitung

  1. temperatureto cool
  2. filtrationfiltered
  3. customthe solvent removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2bd3e86144384b45b2db53708bb5d401
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04853392

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