alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol → HCID 14622775, Verbindung

HRID 1721928Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1721928
[CH2:1]([O:3][CH2:4][N:5]1[C:9]([CH:10]([OH:26])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:13]([Cl:24])[C:12]=2[Cl:25])=[CH:8][CH:7]=[N:6]1)[CH3:2]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:24][C:13]1[C:12]([Cl:25])=[C:11]([C:10]([C:9]2[N:5]([CH2:4][O:3][CH2:1][CH3:2])[N:6]=[CH:7][CH:8]=2)=[O:26])[CH:16]=[CH:15][C:14]=1[O:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]

Komponenten

4

Edukt 1

HCID 20030167alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol

Produkt 1

HCID 14622775HCID 14622775, VerbindungAusbeute 91,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

770 mg of α-(1-ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol and 1.66 g of manganese dioxide are suspended in 30 ml of methylene chloride, and the suspension is stirred at room temperature for 24 hours. The reaction mixture is filtered and the filtrate is evaporated to remove solvent. The residue is triturated with a mixture of isopropyl ether and hexane to give 703 mg of ethyl [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetate as crystals.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is evaporated
  3. customto remove solvent
  4. customThe residue is triturated with a mixture of isopropyl ether and hexane

Quellen und Nachweise

ORD-Eintrag
ord-23b98d0e30544857bf6ad14b79aa5454
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04853404

Notizen zur Reaktion

Wird geladen…